SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling
SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling
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Author / Creator
Biering, Scott B. , Gomes de Sousa, Francielle Tramontini , Tjang, Laurentia V. , Pahmeier, Felix , Zhu, Chi , Ruan, Richard , Blanc, Sophie F. , Patel, Trishna S. , Worthington, Caroline M. , Glasner, Dustin R. , Castillo-Rojas, Bryan , Servellita, Venice , Lo, Nicholas T. N. , Wong, Marcus P. , Warnes, Colin M. , Sandoval, Daniel R. , Clausen, Thomas Mandel , Santos, Yale A. , Fox, Douglas M. , Ortega, Victoria , Näär, Anders M. , Baric, Ralph S. , Stanley, Sarah A. , Aguilar, Hector C. , Esko, Jeffrey D. , Chiu, Charles Y. , Pak, John E. , Beatty, P. Robert and Harris, Eva
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Severe COVID-19 is associated with epithelial and endothelial barrier dysfunction within the lung as well as in distal organs. While it is appreciated that an exaggerated inflammatory response is associated with barrier dysfunction, the triggers of vascular leak are unclear. Here, we report that cell-intrinsic interactions between the Spike (S) gly...
Alternative Titles
Full title
SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling
Authors, Artists and Contributors
Author / Creator
Gomes de Sousa, Francielle Tramontini
Tjang, Laurentia V.
Pahmeier, Felix
Zhu, Chi
Ruan, Richard
Blanc, Sophie F.
Patel, Trishna S.
Worthington, Caroline M.
Glasner, Dustin R.
Castillo-Rojas, Bryan
Servellita, Venice
Lo, Nicholas T. N.
Wong, Marcus P.
Warnes, Colin M.
Sandoval, Daniel R.
Clausen, Thomas Mandel
Santos, Yale A.
Fox, Douglas M.
Ortega, Victoria
Näär, Anders M.
Baric, Ralph S.
Stanley, Sarah A.
Aguilar, Hector C.
Esko, Jeffrey D.
Chiu, Charles Y.
Pak, John E.
Beatty, P. Robert
Harris, Eva
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_4d267ba8c95f4d14abd51985e3d493fd
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4d267ba8c95f4d14abd51985e3d493fd
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-34910-5
