Stacked binding of a PET ligand to Alzheimer’s tau paired helical filaments
Stacked binding of a PET ligand to Alzheimer’s tau paired helical filaments
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Accumulation of filamentous aggregates of tau protein in the brain is a pathological hallmark of Alzheimer’s disease (AD) and many other neurodegenerative tauopathies. The filaments adopt disease-specific cross-β amyloid conformations that self-propagate and are implicated in neuronal loss. Development of molecular diagnostics and therapeutics is o...
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Full title
Stacked binding of a PET ligand to Alzheimer’s tau paired helical filaments
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TN_cdi_doaj_primary_oai_doaj_org_article_4d453a94c2d04d8b84481f4520c5fd9e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4d453a94c2d04d8b84481f4520c5fd9e
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-38537-y
