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Degrado, William F
Journal title:American Men & Women of Science : A Biographical Directory of Today’s Leaders in Physical, Biological and Related Sciences: COO-DUQ, 2022, p.2684-2684
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Degrado, William F
Journal title:American Men & Women of Science : A Biographical Directory of Today’s Leaders in Physical, Biological and Related Sciences: COO-DUQ, 2021, p.2670-2670
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ArticlesPeer ReviewedFull Text
Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity
Author / Creator:Schnaider, Lee ; Brahmachari, Sayanti ; Schmidt, Nathan W. ; Mensa, Bruk ; Shaham-Niv, Shira ; Bychenko, Darya ; Adler-Abramovich, Lihi ; Shimon, Linda J. W. ; Kolusheva, Sofiya ; DeGrado, William F. ; Gazit, Ehud
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-11, Vol.8 (1), p.1365-10, Article 1365
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Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers
Author / Creator:Cady, Sarah D. ; Schmidt-Rohr, Klaus ; Wang, Jun ; Soto, Cinque S. ; DeGrado, William F. ; Hong, Mei
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2010-02, Vol.463 (7281), p.689-692
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De novo design of a transmembrane Zn2+-transporting four-helix bundle
Author / Creator:Joh, Nathan H. ; Wang, Tuo ; Bhate, Manasi P. ; Acharya, Rudresh ; Wu, Yibing ; Grabe, Michael ; Hong, Mei ; Grigoryan, Gevorg ; DeGrado, William F.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2014-12, Vol.346 (6216), p.1520-1524
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Packing of apolar side chains enables accurate design of highly stable membrane proteins
Author / Creator:Mravic, Marco ; Thomaston, Jessica L. ; Tucker, Maxwell ; Solomon, Paige E. ; Liu, Lijun ; DeGrado, William F.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2019-03, Vol.363 (6434), p.1418-1423
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Stacked binding of a PET ligand to Alzheimer’s tau paired helical filaments
Author / Creator:Merz, Gregory E. ; Chalkley, Matthew J. ; Tan, Sophia K. ; Tse, Eric ; Lee, Joanne ; Prusiner, Stanley B. ; Paras, Nick A. ; DeGrado, William F. ; Southworth, Daniel R.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-05, Vol.14 (1), p.3048-11, Article 3048
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ArticlesPeer ReviewedFull Text
Proximity-enhanced SuFEx chemical cross-linker for specific and multitargeting cross-linking mass spectrometry
Author / Creator:Yang, Bing ; Wu, Haifan ; Schnier, Paul D. ; Liu, Yansheng ; Liu, Jun ; Wang, Nanxi ; DeGrado, William F. ; Wang, Lei
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-10, Vol.115 (44), p.11162-11167
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Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions
Author / Creator:Yang, Bing ; Tang, Shibing ; Ma, Cheng ; Li, Shang-Tong ; Shao, Guang-Can ; Dang, Bobo ; DeGrado, William F. ; Dong, Meng-Qiu ; Wang, Peng George ; Ding, Sheng ; Wang, Lei
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-12, Vol.8 (1), p.2240-2240, Article 2240
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Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus
Author / Creator:Wang, Jun ; Wu, Yibing ; Ma, Chunlong ; Fiorin, Giacomo ; Wang, Jizhou ; Pinto, Lawrence H. ; Lamb, Robert A. ; Klein, Michael L. ; DeGrado, William F.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2013-01, Vol.110 (4), p.1315-1320
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Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice
Author / Creator:Stöhr, Jan ; Condello, Carlo ; Watts, Joel C. ; Bloch, Lillian ; Oehler, Abby ; Nick, Mimi ; DeArmond, Stephen J. ; Giles, Kurt ; DeGrado, William F. ; Prusiner, Stanley B.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-07, Vol.111 (28), p.10329-10334
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Allosteric cooperation in a de novo-designed two-domain protein
Author / Creator:Pirro, Fabio ; Schmidt, Nathan ; Lincoff, James ; Widel, Zachary X. ; Polizzi, Nicholas F. ; Liu, Lijun ; Therien, Michael J. ; Grabe, Michael ; Chino, Marco ; Lombardi, Angela ; DeGrado, William F.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2020-12, Vol.117 (52), p.33246-33253
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ArticlesPeer ReviewedFull Text
High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction
Author / Creator:Thomaston, Jessica L. ; Alfonso-Prieto, Mercedes ; Woldeyes, Rahel A. ; Fraser, James S. ; Klein, Michael L. ; Fiorin, Giacomo ; DeGrado, William F.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-11, Vol.112 (46), p.14260-14265
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Structural basis for the function and inhibition of an influenza virus proton channel
Author / Creator:Stouffer, Amanda L. ; Acharya, Rudresh ; Salom, David ; Levine, Anna S. ; Di Costanzo, Luigi ; Soto, Cinque S. ; Tereshko, Valentina ; Nanda, Vikas ; Stayrook, Steven ; DeGrado, William F.
Publisher:London: Nature Publishing Group UK
Journal title:Nature, 2008-01, Vol.451 (7178), p.596-599
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Crystal structure of an amphiphilic foldamer reveals a 48-mer assembly comprising a hollow truncated octahedron
Author / Creator:Pavone, Vincenzo ; Zhang, Shao-Qing ; Merlino, Antonello ; Lombardi, Angela ; Wu, Yibing ; DeGrado, William F.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2014-04, Vol.5 (1), p.3581-3581, Article 3581
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A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi
Author / Creator:dos Reis, Thaila Fernanda ; de Castro, Patrícia Alves ; Bastos, Rafael Wesley ; Pinzan, Camila Figueiredo ; Souza, Pedro F. N. ; Ackloo, Suzanne ; Hossain, Mohammad Anwar ; Drewry, David Harold ; Alkhazraji, Sondus ; Ibrahim, Ashraf S. ; Jo, Hyunil ; Lightfoot, Jorge D. ; Adams, Emily M. ; Fuller, Kevin K. ; deGrado, William F. ; Goldman, Gustavo H.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-04, Vol.14 (1), p.2052-2052, Article 2052
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Computational Design of Virus-Like Protein Assemblies on Carbon Nanotube Surfaces
Author / Creator:Grigoryan, Gevorg ; Kim, Yong Ho ; Acharya, Rudresh ; Axelrod, Kevin ; Jain, Rishabh M. ; Willis, Lauren ; Drndic, Marija ; Kikkawa, James M. ; DeGrado, William F.
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2011-05, Vol.332 (6033), p.1071-1076
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ArticlesPeer ReviewedFull Text
Computational design of a protein crystal
Author / Creator:Lanci, Christopher J ; MacDermaid, Christopher M ; Kang, Seung-gu ; Acharya, Rudresh ; North, Benjamin ; Yang, Xi ; Qiu, X. Jade ; DeGrado, William F ; Saven, Jeffery G
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-05, Vol.109 (19), p.7304-7309
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De Novo Design and in vivo Activity of Conformationally Restrained Antimicrobial Arylamide Foldamers
Author / Creator:Choi, Sungwook ; Isaacs, Andre ; Clements, Dylan ; Liu, Dahui ; Kim, Hyemin ; Scott, Richard W. ; Winkler, Jeffrey D. ; DeGrado, William F. ; Schepartz, Alanna
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2009-04, Vol.106 (17), p.6968-6973
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Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus
Author / Creator:Acharya, Rudresh ; Carnevale, Vincenzo ; Fiorin, Giacomo ; Levine, Benjamin G. ; Polishchuk, Alexei L. ; Balannik, Victoria ; Samish, Ilan ; Lamb, Robert A. ; Pinto, Lawrence H. ; DeGrado, William F. ; Klein, Michael L. ; Rees, Douglas C.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2010-08, Vol.107 (34), p.15075-15080
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Degrado, William F

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Degrado, William F

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Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity

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Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers

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De novo design of a transmembrane Zn2+-transporting four-helix bundle

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Packing of apolar side chains enables accurate design of highly stable membrane proteins

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Stacked binding of a PET ligand to Alzheimer’s tau paired helical filaments

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Proximity-enhanced SuFEx chemical cross-linker for specific and multitargeting cross-linking mass spectrometry

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Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions

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Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus

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Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice

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Allosteric cooperation in a de novo-designed two-domain protein

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High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction

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Structural basis for the function and inhibition of an influenza virus proton channel

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Crystal structure of an amphiphilic foldamer reveals a 48-mer assembly comprising a hollow truncated octahedron

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A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi

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Computational Design of Virus-Like Protein Assemblies on Carbon Nanotube Surfaces

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Computational design of a protein crystal

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De Novo Design and in vivo Activity of Conformationally Restrained Antimicrobial Arylamide Foldamers

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Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus

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