Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal...
Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium
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Author / Creator
Brandt, Raphael , Sell, Thomas , Lüthen, Mareen , Uhlitz, Florian , Klinger, Bertram , Riemer, Pamela , Giesecke-Thiel, Claudia , Schulze, Silvia , El-Shimy, Ismail Amr , Kunkel, Desiree , Fauler, Beatrix , Mielke, Thorsten , Mages, Norbert , Herrmann, Bernhard G. , Sers, Christine , Blüthgen, Nils and Morkel, Markus
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Oncogenic mutations in KRAS or BRAF are frequent in colorectal cancer and activate the ERK kinase. Here, we find graded ERK phosphorylation correlating with cell differentiation in patient-derived colorectal cancer organoids with and without KRAS mutations. Using reporters, single cell transcriptomics and mass cytometry, we observe cell type-specif...
Alternative Titles
Full title
Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium
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Author / Creator
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_4dc8feb67d344b21b71aced69388d1f8
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4dc8feb67d344b21b71aced69388d1f8
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-10954-y
