Stop codon context influences genome-wide stimulation of termination codon readthrough by aminoglyco...
Stop codon context influences genome-wide stimulation of termination codon readthrough by aminoglycosides
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England: eLife Science Publications, Ltd
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English
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England: eLife Science Publications, Ltd
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Stop codon readthrough (SCR) occurs when the ribosome miscodes at a stop codon. Such readthrough events can be therapeutically desirable when a premature termination codon (PTC) is found in a critical gene. To study SCR in vivo in a genome-wide manner, we treated mammalian cells with aminoglycosides and performed ribosome profiling. We find that in...
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Stop codon context influences genome-wide stimulation of termination codon readthrough by aminoglycosides
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TN_cdi_doaj_primary_oai_doaj_org_article_4f26ec2f78ee4199bcedebbff5471f92
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4f26ec2f78ee4199bcedebbff5471f92
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.52611
