Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells
Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Sir2 and insulin/IGF-1 are the major pathways that impinge upon aging in lower organisms. In Caenorhabditis elegans a possible genetic link between Sir2 and the insulin/IGF-1 pathway has been reported. Here we investigate such a link in mammals. We show that Sirt1 positively regulates insulin secretion in pancreatic beta cells. Sirt1 represses the...
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Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells
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TN_cdi_doaj_primary_oai_doaj_org_article_4f48d2d275da44578e958920dcf5b1e2
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4f48d2d275da44578e958920dcf5b1e2
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ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.0040031
