Age-induced nitrative stress decreases retrograde transport of proNGF via TrkA and increases proNGF...
Age-induced nitrative stress decreases retrograde transport of proNGF via TrkA and increases proNGF retrograde transport and neurodegeneration via p75NTR
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Lausanne: Frontiers Research Foundation
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Language
English
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Lausanne: Frontiers Research Foundation
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Contents
Axonal transport of pro nerve growth factor (proNGF) is impaired in aged basal forebrain cholinergic neurons (BFCNs), which is associated with their degeneration. ProNGF is neurotrophic in the presence of its receptor tropomyosin-related kinase A (TrkA) but induces apoptosis via the pan-neurotrophin receptor (p75 NTR ) when TrkA is absent. It is we...
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Full title
Age-induced nitrative stress decreases retrograde transport of proNGF via TrkA and increases proNGF retrograde transport and neurodegeneration via p75NTR
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TN_cdi_doaj_primary_oai_doaj_org_article_50864c653a404e2aa19f454b6ddc7657
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_50864c653a404e2aa19f454b6ddc7657
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ISSN
1662-5099
E-ISSN
1662-5099
DOI
10.3389/fnmol.2023.1241420
