Rapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seedin...
Rapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seeding experiment
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England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Accumulating evidence suggests that the lesions of Parkinson's disease (PD) expand due to transneuronal spreading of fibrils composed of misfolded alpha-synuclein (a-syn), over the course of 5-10 years. However, the precise mechanisms and the processes underlying the spread of these fibril seeds have not been clarified in vivo. Here, we investigate...
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Full title
Rapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seeding experiment
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TN_cdi_doaj_primary_oai_doaj_org_article_50c83c6a542649af85a76996a77e9185
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_50c83c6a542649af85a76996a77e9185
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ISSN
2051-5960
E-ISSN
2051-5960
DOI
10.1186/s40478-018-0587-0
