UV-exposure, endogenous DNA damage, and DNA replication errors shape the spectra of genome changes i...
UV-exposure, endogenous DNA damage, and DNA replication errors shape the spectra of genome changes in human skin
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Publisher
United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Human skin is continuously exposed to environmental DNA damage leading to the accumulation of somatic mutations over the lifetime of an individual. Mutagenesis in human skin cells can be also caused by endogenous DNA damage and by DNA replication errors. The contributions of these processes to the somatic mutation load in the skin of healthy humans...
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Full title
UV-exposure, endogenous DNA damage, and DNA replication errors shape the spectra of genome changes in human skin
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TN_cdi_doaj_primary_oai_doaj_org_article_512c8db43d254b92ad65696179c25e68
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_512c8db43d254b92ad65696179c25e68
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1009302
