HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes
HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes
About this item
Full title
Author / Creator
Mbofung, Rina M. , McKenzie, Jodi A. , Malu, Shruti , Zhang, Min , Peng, Weiyi , Liu, Chengwen , Kuiatse, Isere , Tieu, Trang , Williams, Leila , Devi, Seram , Ashkin, Emily , Xu, Chunyu , Huang, Lu , Zhang, Minying , Talukder, Amjad H. , Tripathi, Satyendra C. , Khong, Hiep , Satani, Nikunj , Muller, Florian L. , Roszik, Jason , Heffernan, Timothy , Allison, James P. , Lizee, Gregory , Hanash, Sam M. , Proia, David , Amaria, Rodabe , Davis, R. Eric and Hwu, Patrick
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
T-cell-based immunotherapies are promising treatments for cancer patients. Although durable responses can be achieved in some patients, many patients fail to respond to these therapies, underscoring the need for improvement with combination therapies. From a screen of 850 bioactive compounds, we identify HSP90 inhibitors as candidates for combinati...
Alternative Titles
Full title
HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes
Authors, Artists and Contributors
Author / Creator
McKenzie, Jodi A.
Malu, Shruti
Zhang, Min
Peng, Weiyi
Liu, Chengwen
Kuiatse, Isere
Tieu, Trang
Williams, Leila
Devi, Seram
Ashkin, Emily
Xu, Chunyu
Huang, Lu
Zhang, Minying
Talukder, Amjad H.
Tripathi, Satyendra C.
Khong, Hiep
Satani, Nikunj
Muller, Florian L.
Roszik, Jason
Heffernan, Timothy
Allison, James P.
Lizee, Gregory
Hanash, Sam M.
Proia, David
Amaria, Rodabe
Davis, R. Eric
Hwu, Patrick
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_51b2a4e16a0b435cabee2477f3975980
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_51b2a4e16a0b435cabee2477f3975980
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-00449-z
