Drug screens of NGLY1 deficiency in worm and fly models reveal catecholamine, NRF2 and anti-inflamma...
Drug screens of NGLY1 deficiency in worm and fly models reveal catecholamine, NRF2 and anti-inflammatory-pathway activation as potential clinical approaches
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Publisher
England: The Company of Biologists Ltd
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Language
English
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Publisher
England: The Company of Biologists Ltd
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Contents
-glycanase 1 (
) deficiency is an ultra-rare and complex monogenic glycosylation disorder that affects fewer than 40 patients globally.
deficiency has been studied in model organisms such as yeast, worms, flies and mice. Proteasomal and mitochondrial homeostasis gene networks are controlled by the evolutionarily conserved transcriptional regu...
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Full title
Drug screens of NGLY1 deficiency in worm and fly models reveal catecholamine, NRF2 and anti-inflammatory-pathway activation as potential clinical approaches
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TN_cdi_doaj_primary_oai_doaj_org_article_51ce9e686f5d4c358384748c161c8bc9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_51ce9e686f5d4c358384748c161c8bc9
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ISSN
1754-8403
E-ISSN
1754-8411
DOI
10.1242/dmm.040576
