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Alanine and glutathione targeting of dopamine- or ibuprofen-coupled polypeptide nanocarriers increas...

Alanine and glutathione targeting of dopamine- or ibuprofen-coupled polypeptide nanocarriers increas...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_523645badf3a447186bcb29bed3fe0ec

Alanine and glutathione targeting of dopamine- or ibuprofen-coupled polypeptide nanocarriers increases both crossing and protective effects on a blood-brain barrier model

About this item

Full title

Alanine and glutathione targeting of dopamine- or ibuprofen-coupled polypeptide nanocarriers increases both crossing and protective effects on a blood-brain barrier model

Publisher

England: BioMed Central Ltd

Journal title

Fluids and barriers of the CNS, 2025-02, Vol.22 (1), p.18-23, Article 18

Language

English

Formats

Publication information

Publisher

England: BioMed Central Ltd

More information

Scope and Contents

Contents

Targeting the blood-brain barrier (BBB) is a key step for effective brain delivery of nanocarriers. We have previously discovered that combinations of BBB nutrient transporter ligands alanine and glutathione (A-GSH), increase the permeability of vesicular and polypeptide nanocarriers containing model cargo across the BBB. Our aim was to investigate...

Alternative Titles

Full title

Alanine and glutathione targeting of dopamine- or ibuprofen-coupled polypeptide nanocarriers increases both crossing and protective effects on a blood-brain barrier model

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_523645badf3a447186bcb29bed3fe0ec

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_523645badf3a447186bcb29bed3fe0ec

Other Identifiers

ISSN

2045-8118

E-ISSN

2045-8118

DOI

10.1186/s12987-025-00623-2

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