Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon p...
Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions
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Author / Creator
Kunová, Nina , Ondrovičová, Gabriela , Bauer, Jacob A. , Krajčovičová, Veronika , Pinkas, Matyáš , Stojkovičová, Barbora , Havalová, Henrieta , Lukáčová, Veronika , Kohútová, Lenka , Košťan, Július , Martináková, Lucia , Baráth, Peter , Nováček, Jiří , Zoll, Sebastian , Kereϊche, Sami , Kutejová, Eva and Pevala, Vladimír
Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Phosphorylation plays a crucial role in the regulation of many fundamental cellular processes. Phosphorylation levels are increased in many cancer cells where they may promote changes in mitochondrial homeostasis. Proteomic studies on various types of cancer identified 17 phosphorylation sites within the human ATP-dependent protease Lon, which degr...
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Full title
Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions
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TN_cdi_doaj_primary_oai_doaj_org_article_5368c6745a034ecba542e4c421929eab
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5368c6745a034ecba542e4c421929eab
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-024-60030-9
