Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversal
Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversal
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
The persistence of HIV-1 in long-lived latent reservoirs during suppressive antiretroviral therapy (ART) remains one of the principal barriers to a functional cure. Blocks to transcriptional elongation play a central role in maintaining the latent state, and several latency reversal strategies focus on the release of positive transcription elongati...
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Full title
Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversal
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TN_cdi_doaj_primary_oai_doaj_org_article_5390f996c27f49f3abec55b1597aae84
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5390f996c27f49f3abec55b1597aae84
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1012083
