Unravelling druggable signalling networks that control F508del-CFTR proteostasis
Unravelling druggable signalling networks that control F508del-CFTR proteostasis
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Author / Creator
Hegde, Ramanath Narayana , Parashuraman, Seetharaman , Iorio, Francesco , Ciciriello, Fabiana , Capuani, Fabrizio , Carissimo, Annamaria , Carrella, Diego , Belcastro, Vincenzo , Subramanian, Advait , Bounti, Laura , Persico, Maria , Carlile, Graeme , Galietta, Luis , Thomas, David Y , Di Bernardo, Diego and Luini, Alberto
Publisher
England: eLife Sciences Publications Ltd
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English
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England: eLife Sciences Publications Ltd
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Contents
Cystic fibrosis (CF) is caused by mutations in CF transmembrane conductance regulator (CFTR). The most frequent mutation (F508del-CFTR) results in altered proteostasis, that is, in the misfolding and intracellular degradation of the protein. The F508del-CFTR proteostasis machinery and its homeostatic regulation are well studied, while the question...
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Full title
Unravelling druggable signalling networks that control F508del-CFTR proteostasis
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TN_cdi_doaj_primary_oai_doaj_org_article_539e56c235594b23a5b171eb590f887b
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_539e56c235594b23a5b171eb590f887b
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.10365
