BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation...
BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The BRCA2 tumor suppressor protects genome integrity by promoting homologous recombination-based repair of DNA breaks, stability of stalled DNA replication forks and DNA damage-induced cell cycle checkpoints. BRCA2 deficient cells display the radio-resistant DNA synthesis (RDS) phenotype, however the mechanism has remained elusive. Here we show tha...
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BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage
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TN_cdi_doaj_primary_oai_doaj_org_article_547aeddfdeaa407a9247db9195fbad1b
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_547aeddfdeaa407a9247db9195fbad1b
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-26227-6
