A high affinity switch for cAMP in the HCN pacemaker channels
A high affinity switch for cAMP in the HCN pacemaker channels
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Binding of cAMP to Hyperpolarization activated cyclic nucleotide gated (HCN) channels facilitates pore opening. It is unclear why the isolated cyclic nucleotide binding domain (CNBD) displays in vitro lower affinity for cAMP than the full-length channel in patch experiments. Here we show that HCN are endowed with an affinity switch for cAMP. Alpha...
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Full title
A high affinity switch for cAMP in the HCN pacemaker channels
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TN_cdi_doaj_primary_oai_doaj_org_article_54ee296cfd5a4b9b8c10a343ba531e63
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_54ee296cfd5a4b9b8c10a343ba531e63
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-45136-y
