Improvement of the affinity of an anti-rat P2X4 receptor antibody by introducing electrostatic inter...
Improvement of the affinity of an anti-rat P2X4 receptor antibody by introducing electrostatic interactions
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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We have recently developed a mouse monoclonal antibody (12–10H) binding to the head domain region in rat P2X4 receptor (rP2X4R, which is crucial for the pathogenesis of neuropathic pain) expressed on the cell with the highest binding affinity (
K
D
= 20 nM). However, the 12–10H antibody failed to detect endogenously expressed P2X4Rs in mi...
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Full title
Improvement of the affinity of an anti-rat P2X4 receptor antibody by introducing electrostatic interactions
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TN_cdi_doaj_primary_oai_doaj_org_article_56486021f0394e62b51df59f5de03618
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_56486021f0394e62b51df59f5de03618
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-03784-w
