Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in...
Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice
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Author / Creator
Vi, Linda , Baht, Gurpreet S. , Soderblom, Erik J. , Whetstone, Heather , Wei, Qingxia , Furman, Bridgette , Puviindran, Vijitha , Nadesan, Puviindran , Foster, Matthew , Poon, Raymond , White, James P. , Yahara, Yasuhito , Ng, Adeline , Barrientos, Tomasa , Grynpas, Marc , Mosely, M. Arthur and Alman, Benjamin A.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The pace of repair declines with age and, while exposure to a young circulation can rejuvenate fracture repair, the cell types and factors responsible for rejuvenation are unknown. Here we report that young macrophage cells produce factors that promote osteoblast differentiation of old bone marrow stromal cells. Heterochronic parabiosis exploiting...
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Full title
Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice
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TN_cdi_doaj_primary_oai_doaj_org_article_56adb114e6924a34bf6b3b26daebff26
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_56adb114e6924a34bf6b3b26daebff26
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-07666-0
