A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in respons...
A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations
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Publisher
England: The Company of Biologists Ltd
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Language
English
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Publisher
England: The Company of Biologists Ltd
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Contents
Activation of the Wnt/β-catenin pathway occurs in the vast majority of colorectal cancers. However, the outcome of the disease varies markedly from individual to individual, even within the same tumor stage. This heterogeneity is governed to a great extent by the genetic make-up of individual tumors and the combination of oncogenic mutations. In or...
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Full title
A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations
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TN_cdi_doaj_primary_oai_doaj_org_article_58867a4685854a29935bce90674df65b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_58867a4685854a29935bce90674df65b
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ISSN
1754-8403,1754-8411
E-ISSN
1754-8411,1754-8403
DOI
10.1242/dmm.019844
