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ArticlesPeer ReviewedFull Text
IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization
Author / Creator:Eissmann, Moritz F. ; Dijkstra, Christine ; Jarnicki, Andrew ; Phesse, Toby ; Brunnberg, Jamina ; Poh, Ashleigh R. ; Etemadi, Nima ; Tsantikos, Evelyn ; Thiem, Stefan ; Huntington, Nicholas D. ; Hibbs, Margaret L. ; Boussioutas, Alex ; Grimbaldeston, Michele A. ; Buchert, Michael ; O’Donoghue, Robert J. J. ; Masson, Frederick ; Ernst, Matthias
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-06, Vol.10 (1), p.2735-16, Article 2735
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ArticlesPeer ReviewedFull Text
A tuft cell - ILC2 signaling circuit provides therapeutic targets to inhibit gastric metaplasia and tumor development
Author / Creator:O’Keefe, Ryan N. ; Carli, Annalisa L. E. ; Baloyan, David ; Chisanga, David ; Shi, Wei ; Afshar-Sterle, Shoukat ; Eissmann, Moritz F. ; Poh, Ashleigh R. ; Pal, Bhupinder ; Seillet, Cyril ; Locksley, Richard M. ; Ernst, Matthias ; Buchert, Michael
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-10, Vol.14 (1), p.6872-6872, Article 6872
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ArticlesPeer ReviewedFull Text
mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice
Author / Creator:Thiem, Stefan ; Pierce, Thomas P ; Palmieri, Michelle ; Putoczki, Tracy L ; Buchert, Michael ; Preaudet, Adele ; Farid, Ryan O ; Love, Chris ; Catimel, Bruno ; Lei, Zhengdeng ; Rozen, Steve ; Gopalakrishnan, Veena ; Schaper, Fred ; Hallek, Michael ; Boussioutas, Alex ; Tan, Patrick ; Jarnicki, Andrew ; Ernst, Matthias
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2013-02, Vol.123 (2), p.767-781
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ArticlesPeer ReviewedFull Text
Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth
Author / Creator:Thilakasiri, Pathum ; Huynh, Jennifer ; Poh, Ashleigh R ; Tan, Chin Wee ; Nero, Tracy L ; Tran, Kelly ; Parslow, Adam C ; Afshar‐Sterle, Shoukat ; Baloyan, David ; Hannan, Natalie J ; Buchert, Michael ; Scott, Andrew Mark ; Griffin, Michael DW ; Hollande, Frederic ; Parker, Michael W ; Putoczki, Tracy L ; Ernst, Matthias ; Chand, Ashwini L
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2019-04, Vol.11 (4), p.1-n/a
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Newsletter articlesFull Text
Patents; Patent Application Titled "Methods of Treating Diseases Characterized by Excessive Wnt Signalling" Published Online (USPTO 20160045498)
Publisher:Atlanta: NewsRx
Journal title:Cancer Gene Therapy Week, 2016, p.44
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ArticlesPeer ReviewedFull Text
Methods to Examine Tight Junction Physiology in Cancer Stem Cells: TEER, Paracellular Permeability, and Dilution Potential Measurements
Author / Creator:Buchert, Michael ; Turksen, Kursad ; Hollande, Frédéric
Publisher:New York: Humana Press Inc
Journal title:Stem cell reviews, 2012-09, Vol.8 (3), p.1030-1034
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ArticlesPeer ReviewedFull Text
Symplekin promotes tumorigenicity by up-regulating claudin-2 expression
Author / Creator:Buchert, Michael ; Papin, Marina ; Bonnans, Caroline ; Darido, Charbel ; Raye, Warren S ; Garambois, Véronique ; Pélegrin, André ; Bourgaux, Jean-François ; Pannequin, Julie ; Joubert, Dominique ; Hollande, Frédéric
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2010-02, Vol.107 (6), p.2628-2633
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ArticlesPeer ReviewedFull Text
A Mouse Model for the Rapid and Binomial Assessment of Putative WNT/β-Catenin Signalling Inhibitors
Author / Creator:Tse, Janson ; O’Keefe, Ryan ; Rigopolous, Angela ; Carli, Annalisa L. E ; Waaler, Jo ; Krauss, Stefan ; Ernst, Matthias ; Buchert, Michael
Publisher:Basel: MDPI AG
Journal title:Biomedicines, 2023-10, Vol.11 (10), p.2719
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ArticlesPeer ReviewedFull Text
Structure-Guided Prediction of the Functional Impact of DCLK1 Mutations on Tumorigenesis
Author / Creator:Carli, Annalisa L E ; Hardy, Joshua M ; Hoblos, Hanadi ; Ernst, Matthias ; Lucet, Isabelle S ; Buchert, Michael
Publisher:Switzerland: MDPI AG
Journal title:Biomedicines, 2023-03, Vol.11 (3), p.990
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ArticlesPeer ReviewedFull Text
Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo
Author / Creator:Buchert, Michael ; Athineos, Dimitris ; Abud, Helen E ; Burke, Zoe D ; Faux, Maree C ; Samuel, Michael S ; Jarnicki, Andrew G ; Winbanks, Catherine E ; Newton, Ian P ; Meniel, Valerie S ; Suzuki, Hiromu ; Stacker, Steven A ; Näthke, Inke S ; Tosh, David ; Huelsken, Joerg ; Clarke, Alan R ; Heath, Joan K ; Sansom, Owen J ; Ernst, Matthias
Publisher:United States: Public Library of Science
Journal title:PLoS genetics, 2010-01, Vol.6 (1), p.e1000816-e1000816
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ArticlesPeer ReviewedFull Text
Glycoprotein A33 deficiency: a new mouse model of impaired intestinal epithelial barrier function and inflammatory disease
Author / Creator:Williams, Benjamin B ; Tebbutt, Niall C ; Buchert, Michael ; Putoczki, Tracy L ; Doggett, Karen ; Bao, Shisan ; Johnstone, Cameron N ; Masson, Frederick ; Hollande, Frederic ; Burgess, Antony W ; Scott, Andrew M ; Ernst, Matthias ; Heath, Joan K
Publisher:England: The Company of Biologists Ltd
Journal title:Disease models & mechanisms, 2015-08, Vol.8 (8), p.805-815
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ArticlesPeer ReviewedFull Text
BECLIN1 is essential for intestinal homeostasis involving autophagy-independent mechanisms through its function in endocytic trafficking
Author / Creator:Tran, Sharon ; Juliani, Juliani ; Harris, Tiffany J. ; Evangelista, Marco ; Ratcliffe, Julian ; Ellis, Sarah L. ; Baloyan, David ; Reehorst, Camilla M. ; Nightingale, Rebecca ; Luk, Ian Y. ; Jenkins, Laura J. ; Ghilas, Sonia ; Yakou, Marina H. ; Inguanti, Chantelle ; Johnson, Chad ; Buchert, Michael ; Lee, James C. ; De Cruz, Peter ; Duszyc, Kinga ; Gleeson, Paul A. ; Kile, Benjamin T. ; Mielke, Lisa A. ; Yap, Alpha S. ; Mariadason, John M. ; Fairlie, W. Douglas ; Lee, Erinna F.
Publisher:London: Nature Publishing Group UK
Journal title:Communications biology, 2024-02, Vol.7 (1), p.209-13, Article 209
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ArticlesPeer ReviewedFull Text
A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations
Author / Creator:Buchert, Michael ; Rohde, Franziska ; Eissmann, Moritz ; Tebbutt, Niall ; Williams, Ben ; Tan, Chin Wee ; Owen, Alexander ; Hirokawa, Yumiko ; Gnann, Alexandra ; Orend, Gertraud ; Orner, Gayle ; Dashwood, Rod H ; Heath, Joan K ; Ernst, Matthias ; Janssen, Klaus-Peter
Publisher:England: The Company of Biologists Ltd
Journal title:Disease models & mechanisms, 2015-11, Vol.8 (11), p.1361-1373
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ArticlesPeer ReviewedFull Text
Transcription factor AP-2 essential for cranial closure and craniofacial development
Author / Creator:Schorle, Hubert ; Meier, Pascal ; Buchert, Michael ; Jaenisch, Rudolf ; Mitchell, Pamela J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 1996-05, Vol.381 (6579), p.235-238
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ArticlesPeer ReviewedFull Text
Glycoprotein A33 deficiency: a new model of impaired intestinal epithelial barrier function and inflammatory disease
Author / Creator:Williams, Benjamin B. ; Tebbutt, Niall C. ; Buchert, Michael ; Putoczki, Tracy L. ; Doggett, Karen ; Bao, Shisan ; Johnstone, Cameron N. ; Masson, Frederick ; Hollande, Frederic ; Burgess, Antony W. ; Scott, Andrew M. ; Ernst, Matthias ; Heath, Joan K.
Journal title:Disease models & mechanisms, 2015-01
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ArticlesPeer ReviewedFull Text
Deep learning exploration of single-cell and spatially resolved cancer transcriptomics to unravel tumour heterogeneity
Author / Creator:Halawani, Raid ; Buchert, Michael ; Chen, Yi-Ping Phoebe
Publisher:United States: Elsevier Ltd
Journal title:Computers in biology and medicine, 2023-09, Vol.164, p.107274-107274, Article 107274
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ArticlesPeer ReviewedFull Text
Onco-miR-21 Promotes Stat3-Dependent Gastric Cancer Progression
Author / Creator:Tse, Janson ; Pierce, Thomas ; Carli, Annalisa L E ; Alorro, Mariah G ; Thiem, Stefan ; Marcusson, Eric G ; Ernst, Matthias ; Buchert, Michael
Publisher:Switzerland: MDPI AG
Journal title:Cancers, 2022-01, Vol.14 (2), p.264
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ArticlesPeer ReviewedFull Text
STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice
Author / Creator:Ernst, Matthias ; Najdovska, Meri ; Grail, Dianne ; Lundgren-May, Therese ; Buchert, Michael ; Tye, Hazel ; Matthews, Vance B ; Armes, Jane ; Bhathal, Prithi S ; Hughes, Norman R ; Marcusson, Eric G ; Karras, James G ; Na, Songqing ; Sedgwick, Jonathon D ; Hertzog, Paul J ; Jenkins, Brendan J
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2008-05, Vol.118 (5), p.1727-1738
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ArticlesPeer ReviewedFull Text
mTORCI inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice
Author / Creator:Thiem, Stefan ; Pierce, Thomas P ; Palmieri, Michelle ; Putoczki, Tracy L ; Buchert, Michael ; Preaudet, Adele ; Farid, Ryan O ; Love, Chris ; Catimel, Bruno ; Lei, Zhengdeng ; Rozen, Steve ; Gopalakrishnan, Veena ; Schaper, Fred ; Hallek, Michael ; Boussioutas, Alex ; Tan, Patrick ; Jarnicki, Andrew ; Ernst, Matthias
Publisher:Ann Arbor: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2013-02, Vol.123 (2), p.767-767
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ArticlesPeer ReviewedFull Text
Ryk-deficient mice exhibit craniofacial defects associated with perturbed Eph receptor crosstalk
Author / Creator:Halford, Michael M. ; Armes, Jane ; Buchert, Michael ; Meskenaite, Virginia ; Grail, Dianne ; Hibbs, Margaret L. ; Wilks, Andrew F. ; Farlie, Peter G. ; Newgreen, Don F. ; Hovens, Christopher M. ; Stacker, Steven A.
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2000-08, Vol.25 (4), p.414-418
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IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization

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A tuft cell - ILC2 signaling circuit provides therapeutic targets to inhibit gastric metaplasia and tumor development

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mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice

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Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth

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Patents; Patent Application Titled "Methods of Treating Diseases Characterized by Excessive Wnt Signalling" Published Online (USPTO 20160045498)

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Methods to Examine Tight Junction Physiology in Cancer Stem Cells: TEER, Paracellular Permeability, and Dilution Potential Measurements

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Symplekin promotes tumorigenicity by up-regulating claudin-2 expression

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A Mouse Model for the Rapid and Binomial Assessment of Putative WNT/β-Catenin Signalling Inhibitors

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Structure-Guided Prediction of the Functional Impact of DCLK1 Mutations on Tumorigenesis

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Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo

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Glycoprotein A33 deficiency: a new mouse model of impaired intestinal epithelial barrier function and inflammatory disease

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BECLIN1 is essential for intestinal homeostasis involving autophagy-independent mechanisms through its function in endocytic trafficking

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A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations

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Transcription factor AP-2 essential for cranial closure and craniofacial development

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Glycoprotein A33 deficiency: a new model of impaired intestinal epithelial barrier function and inflammatory disease

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Deep learning exploration of single-cell and spatially resolved cancer transcriptomics to unravel tumour heterogeneity

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Onco-miR-21 Promotes Stat3-Dependent Gastric Cancer Progression

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STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice

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mTORCI inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice

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Ryk-deficient mice exhibit craniofacial defects associated with perturbed Eph receptor crosstalk

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