Deletion of the von Hippel–Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor‐m...
Deletion of the von Hippel–Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor‐mediated adaptation to hypoxia
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London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Mutations of the von Hippel–Lindau (
VHL)
gene are associated with pheochromocytomas and paragangliomas, but the role of VHL in sympathoadrenal homeostasis is unknown. We generated mice lacking Vhl in catecholaminergic cells. They exhibited atrophy of the carotid body (CB), adrenal medulla, and sympathetic ganglia.
Vhl
‐null animals had...
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Deletion of the von Hippel–Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor‐mediated adaptation to hypoxia
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TN_cdi_doaj_primary_oai_doaj_org_article_58cd0b71429c44be98ddd6d219816172
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_58cd0b71429c44be98ddd6d219816172
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ISSN
1757-4676
E-ISSN
1757-4684
DOI
10.15252/emmm.201404153
