Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction
Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction
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Author / Creator
Yin, Mingzhu , Guo, Ying , Hu, Rui , Cai, Wesley L. , Li, Yao , Pei, Shiyao , Sun, Hongyin , Peng, Cong , Li, Jiali , Ye, Rui , Yang, Qiaohong , Wang, Nenghui , Tao, Yongguang , Chen, Xiang and Yan, Qin
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Small molecule inhibitor of the bromodomain and extraterminal domain (BET) family proteins is a promising option for cancer treatment. However, current BET inhibitors are limited by their potency or oral bioavailability. Here we report the discovery and characterization of NHWD-870, a BET inhibitor that is more potent than three major clinical stag...
Alternative Titles
Full title
Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_59a306de0a994d95ae774f48771aeb95
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_59a306de0a994d95ae774f48771aeb95
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-15290-0
