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Reactivated endogenous retroviruses promote protein aggregate spreading

Reactivated endogenous retroviruses promote protein aggregate spreading

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_59bc77799ee240d9b3249e422cd48dea

Reactivated endogenous retroviruses promote protein aggregate spreading

About this item

Full title

Reactivated endogenous retroviruses promote protein aggregate spreading

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2023-08, Vol.14 (1), p.5034-19, Article 5034

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Prion-like spreading of protein misfolding is a characteristic of neurodegenerative diseases, but the exact mechanisms of intercellular protein aggregate dissemination remain unresolved. Evidence accumulates that endogenous retroviruses, remnants of viral germline infections that are normally epigenetically silenced, become upregulated in neurodege...

Alternative Titles

Full title

Reactivated endogenous retroviruses promote protein aggregate spreading

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_59bc77799ee240d9b3249e422cd48dea

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_59bc77799ee240d9b3249e422cd48dea

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-023-40632-z

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