Carboplatin in metastatic castration-resistant prostate cancer patients with molecular alterations o...
Carboplatin in metastatic castration-resistant prostate cancer patients with molecular alterations of the DNA damage repair pathway: the PRO-CARBO phase II trial
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Author / Creator
Coquan, Elodie , Penel, Nicolas , Lequesne, Justine , Leman, Raphaël , Lavaud, Pernelle , Neviere, Zoé , Brachet, Pierre-Emmanuel , Meriaux, Emeline , Carnot, Aurélien , Boutrois, Jérémy , Castera, Marie , Goardon, Nicolas , Muller, Etienne , Leconte, Alexandra , Thiery-Vuillemin, Antoine , Clarisse, Bénédicte and Joly, Florence
Publisher
London, England: SAGE Publications
Journal title
Language
English
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Publication information
Publisher
London, England: SAGE Publications
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Contents
Introduction:
DNA damage repair genes are altered in 20–35% of metastatic castration-resistant prostate cancer (mCRPC). Poly-ADP (Adénosine Diphosphate)-ribose polymerase inhibitors (PARPi) showed significant activity for these selected tumors, especially with homologous recombination repair (HRR) deficiency. These alterations could also predict...
Alternative Titles
Full title
Carboplatin in metastatic castration-resistant prostate cancer patients with molecular alterations of the DNA damage repair pathway: the PRO-CARBO phase II trial
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TN_cdi_doaj_primary_oai_doaj_org_article_5a69b905bc4946d5bd1a26e1aca0aa30
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5a69b905bc4946d5bd1a26e1aca0aa30
Other Identifiers
ISSN
1756-2872
E-ISSN
1756-2880
DOI
10.1177/17562872241229876
