Tweaking Progranulin Expression: Therapeutic Avenues and Opportunities
Tweaking Progranulin Expression: Therapeutic Avenues and Opportunities
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Publisher
Lausanne: Frontiers Research Foundation
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Language
English
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Lausanne: Frontiers Research Foundation
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Contents
Frontotemporal dementia (FTD) is a neurodegenerative disease, leading to behavioral changes and language difficulties. Heterozygous loss-of-function mutations in
progranulin
(
GRN
) induce haploinsufficiency of the protein and are associated with up to one-third of all genetic FTD cases worldwide. While the loss of GRN is primarily asso...
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Full title
Tweaking Progranulin Expression: Therapeutic Avenues and Opportunities
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TN_cdi_doaj_primary_oai_doaj_org_article_5c99debbd58a4f338d0756a975e5bd57
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5c99debbd58a4f338d0756a975e5bd57
Other Identifiers
ISSN
1662-5099
E-ISSN
1662-5099
DOI
10.3389/fnmol.2021.713031
