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Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon...

Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5cf8f3dde5cd47a1a85ac40483be92aa

Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function

About this item

Full title

Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function

Publisher

England: eLife Science Publications, Ltd

Journal title

eLife, 2016-01, Vol.5

Language

English

Formats

Publication information

Publisher

England: eLife Science Publications, Ltd

More information

Scope and Contents

Contents

Metzincin metalloproteases have major roles in intercellular communication by modulating the function of membrane proteins. One of the proteases is the a-disintegrin-and-metalloprotease 10 (ADAM10) which acts as alpha-secretase of the Alzheimer's disease amyloid precursor protein. ADAM10 is also required for neuronal network functions in murine bra...

Alternative Titles

Full title

Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_5cf8f3dde5cd47a1a85ac40483be92aa

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5cf8f3dde5cd47a1a85ac40483be92aa

Other Identifiers

ISSN

2050-084X

E-ISSN

2050-084X

DOI

10.7554/eLife.12748

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