Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutat...
Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Targeted protein degradation is a promising drug development paradigm. Here we leverage this strategy to develop a new class of small molecule antivirals that induce proteasomal degradation of viral proteins. Telaprevir, a reversible-covalent inhibitor that binds to the hepatitis C virus (HCV) protease active site is conjugated to ligands that recr...
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Full title
Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations
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TN_cdi_doaj_primary_oai_doaj_org_article_5d5842f94e6549918072db60b50a3ebb
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5d5842f94e6549918072db60b50a3ebb
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-11429-w
