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ArticlesPeer ReviewedFull Text
A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density
Author / Creator:Pearce, Nicholas M. ; Krojer, Tobias ; Bradley, Anthony R. ; Collins, Patrick ; Nowak, Radosław P. ; Talon, Romain ; Marsden, Brian D. ; Kelm, Sebastian ; Shi, Jiye ; Deane, Charlotte M. ; von Delft, Frank
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-04, Vol.8 (1), p.15123-15123, Article 15123
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Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome
Author / Creator:Donovan, Katherine A ; An, Jian ; Nowak, Radosław P ; Yuan, Jingting C ; Fink, Emma C ; Berry, Bethany C ; Ebert, Benjamin L ; Fischer, Eric S
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2018-08, Vol.7
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Plasticity in binding confers selectivity in ligand-induced protein degradation
Author / Creator:Nowak, Radosław P. ; DeAngelo, Stephen L. ; Buckley, Dennis ; He, Zhixiang ; Donovan, Katherine A. ; An, Jian ; Safaee, Nozhat ; Jedrychowski, Mark P. ; Ponthier, Charles M. ; Ishoey, Mette ; Zhang, Tinghu ; Mancias, Joseph D. ; Gray, Nathanael S. ; Bradner, James E. ; Fischer, Eric S.
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2018-07, Vol.14 (7), p.706-714
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Small-molecule-induced polymerization triggers degradation of BCL6
Author / Creator:Słabicki, Mikołaj ; Yoon, Hojong ; Koeppel, Jonas ; Nitsch, Lena ; Roy Burman, Shourya S. ; Di Genua, Cristina ; Donovan, Katherine A. ; Sperling, Adam S. ; Hunkeler, Moritz ; Tsai, Jonathan M. ; Sharma, Rohan ; Guirguis, Andrew ; Zou, Charles ; Chudasama, Priya ; Gasser, Jessica A. ; Miller, Peter G. ; Scholl, Claudia ; Fröhling, Stefan ; Nowak, Radosław P. ; Fischer, Eric S. ; Ebert, Benjamin L.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2020-12, Vol.588 (7836), p.164-168
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Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15
Author / Creator:Faust, Tyler B. ; Yoon, Hojong ; Nowak, Radosław P. ; Donovan, Katherine A. ; Li, Zhengnian ; Cai, Quan ; Eleuteri, Nicholas A. ; Zhang, Tinghu ; Gray, Nathanael S. ; Fischer, Eric S.
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2020-01, Vol.16 (1), p.7-14
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Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations
Author / Creator:de Wispelaere, Mélissanne ; Du, Guangyan ; Donovan, Katherine A. ; Zhang, Tinghu ; Eleuteri, Nicholas A. ; Yuan, Jingting C. ; Kalabathula, Joann ; Nowak, Radosław P. ; Fischer, Eric S. ; Gray, Nathanael S. ; Yang, Priscilla L.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-08, Vol.10 (1), p.3468-11, Article 3468
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Structural basis of regulated m7G tRNA modification by METTL1–WDR4
Author / Creator:Li, Jiazhi ; Wang, Longfei ; Hahn, Quentin ; Nowak, Radosław P. ; Viennet, Thibault ; Orellana, Esteban A. ; Roy Burman, Shourya S. ; Yue, Hong ; Hunkeler, Moritz ; Fontana, Pietro ; Wu, Hao ; Arthanari, Haribabu ; Fischer, Eric S. ; Gregory, Richard I.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2023-01, Vol.613 (7943), p.391-397
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Acute pharmacological degradation of Helios destabilizes regulatory T cells
Author / Creator:Wang, Eric S. ; Verano, Alyssa L. ; Nowak, Radosław P. ; Yuan, J. Christine ; Donovan, Katherine A. ; Eleuteri, Nicholas A. ; Yue, Hong ; Ngo, Kenneth H. ; Lizotte, Patrick H. ; Gokhale, Prafulla C. ; Gray, Nathanael S. ; Fischer, Eric S.
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2021-06, Vol.17 (6), p.711-717
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Tubulin Resists Degradation by Cereblon-Recruiting PROTACs
Author / Creator:Gasic, Ivana ; Groendyke, Brian J. ; Nowak, Radosław P. ; Yuan, J. Christine ; Kalabathula, Joann ; Fischer, Eric S. ; Gray, Nathanael S. ; Mitchison, Timothy J.
Publisher:Switzerland: MDPI AG
Journal title:Cells (Basel, Switzerland), 2020-04, Vol.9 (5), p.1083
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Targeted protein degradation as a powerful research tool in basic biology and drug target discovery
Author / Creator:Wu, Tao ; Yoon, Hojong ; Xiong, Yuan ; Dixon-Clarke, Sarah E. ; Nowak, Radosław P. ; Fischer, Eric S.
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2020-07, Vol.27 (7), p.605-614
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MEN1 mutations mediate clinical resistance to menin inhibition
Author / Creator:Perner, Florian ; Stein, Eytan M. ; Wenge, Daniela V. ; Singh, Sukrit ; Kim, Jeonghyeon ; Apazidis, Athina ; Rahnamoun, Homa ; Anand, Disha ; Marinaccio, Christian ; Hatton, Charlie ; Wen, Yanhe ; Stone, Richard M. ; Schaller, David ; Mowla, Shoron ; Xiao, Wenbin ; Gamlen, Holly A. ; Stonestrom, Aaron J. ; Persaud, Sonali ; Ener, Elizabeth ; Cutler, Jevon A. ; Doench, John G. ; McGeehan, Gerard M. ; Volkamer, Andrea ; Chodera, John D. ; Nowak, Radosław P. ; Fischer, Eric S. ; Levine, Ross L. ; Armstrong, Scott A. ; Cai, Sheng F.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2023-03, Vol.615 (7954), p.913-919
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ArticlesPeer ReviewedFull Text
Serological testing for SARS-CoV-2 antibodies of employees shows low transmission working in a cancer center
Author / Creator:Meyerhardt, Jeffrey A. ; Yue, Hong ; Nowak, Radosław P. ; Brais, Lauren ; Ma, Chao ; Johnson, Samantha ; Harrod, Joanna ; Burman, Shourya S. Roy ; Hendrickson, Lynn M. ; Fischinger, Stephanie ; Alter, Galit ; Hahn, William ; Johnson, Bruce E. ; Fischer, Eric S.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2022-04, Vol.17 (4), p.e0266791-e0266791
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Structural analysis of human KDM5B guides histone demethylase inhibitor development
Author / Creator:Johansson, Catrine ; Velupillai, Srikannathasan ; Tumber, Anthony ; Szykowska, Aleksandra ; Hookway, Edward S ; Nowak, Radoslaw P ; Strain-Damerell, Claire ; Gileadi, Carina ; Philpott, Martin ; Burgess-Brown, Nicola ; Wu, Na ; Kopec, Jola ; Nuzzi, Andrea ; Steuber, Holger ; Egner, Ursula ; Badock, Volker ; Munro, Shonagh ; LaThangue, Nicholas B ; Westaway, Sue ; Brown, Jack ; Athanasou, Nick ; Prinjha, Rab ; Brennan, Paul E ; Oppermann, Udo
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2016-07, Vol.12 (7), p.539-545
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Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders
Author / Creator:Yen-Der, Li ; Ma, Michelle W ; Hassan, Muhammad Murtaza ; Hunkeler, Moritz ; Teng, Mingxing ; Kedar Puvar ; Lumpkin, Ryan ; Sandoval, Brittany ; Jin, Cyrus Y ; Ficarro, Scott B ; Wang, Michelle Y ; Xu, Shawn ; Groendyke, Brian J ; Sigua, Logan H ; Tavares, Isidoro ; Zou, Charles ; Tsai, Jonathan M ; Park, Paul M C ; Yoon, Hojong ; Majewski, Felix C ; Marto, Jarrod A ; Qi, Jun ; Nowak, Radoslaw P ; Donovan, Katherine A ; Slabicki, Mikolaj ; Gray, Nathanael S ; Fischer, Eric S ; Ebert, Benjamin L
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2023-02
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Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4
Author / Creator:Li, Jiazhi ; Wang, Longfei ; Hahn, Quentin ; Nowak, Radosław P ; Viennet, Thibault ; Orellana, Esteban A ; Roy Burman, Shourya S ; Yue, Hong ; Hunkeler, Moritz ; Fontana, Pietro ; Wu, Hao ; Arthanari, Haribabu ; Fischer, Eric S ; Gregory, Richard I
Publisher:England
Journal title:Nature (London), 2023-01, Vol.613 (7943), p.391
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Serological testing for SARS-CoV-2 antibodies of employees shows low transmission working in a cancer center Serological testing for SARS-CoV-2 antibodies of employees shows low transmission working i...
Author / Creator:Jeffrey A. Meyerhardt ; Hong Yue ; Radosław P. Nowak ; Lauren Brais ; Chao Ma ; Samantha Johnson ; Joanna Harrod ; Shourya S. Roy Burman ; Lynn M. Hendrickson ; Stephanie Fischinger ; Galit Alter ; William Hahn ; Bruce E. Johnson ; Eric S. Fischer
Publisher:Public Library of Science (PLoS)
Journal title:PloS one, 2022-01, Vol.17 (4)
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E3-specific degrader discovery by dynamic tracing of substrate receptor abundance
Author / Creator:Hanzl, Alexander ; Barone, Eleonora ; Bauer, Sophie ; Hong, Yue ; Nowak, Radoslaw P ; Hahn, Elisa ; Pankevich, Eugenia V ; Koren, Anna ; Kubicek, Stefan ; Fischer, Eric S ; Winter, Georg E
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2022-10
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A Multi-Crystal Method for Extracting Obscured Signal from Crystallographic Electron Density
Author / Creator:Pearce, Nicholas ; Bradley, Anthony Richard ; Collins, Patrick ; Krojer, Tobias ; Nowak, Radoslaw ; Talon, Romain ; Marsden, Brian D ; Kelm, Sebastian ; Shi, Jiye ; Deane, Charlotte ; Frank Von Delft
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2016-09
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A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density

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Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome

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Plasticity in binding confers selectivity in ligand-induced protein degradation

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Small-molecule-induced polymerization triggers degradation of BCL6

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Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15

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Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations

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Structural basis of regulated m7G tRNA modification by METTL1–WDR4

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Acute pharmacological degradation of Helios destabilizes regulatory T cells

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Tubulin Resists Degradation by Cereblon-Recruiting PROTACs

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Targeted protein degradation as a powerful research tool in basic biology and drug target discovery

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MEN1 mutations mediate clinical resistance to menin inhibition

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Serological testing for SARS-CoV-2 antibodies of employees shows low transmission working in a cancer center

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Structural analysis of human KDM5B guides histone demethylase inhibitor development

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Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders

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Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4

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Serological testing for SARS-CoV-2 antibodies of employees shows low transmission working in a cancer center Serological testing for SARS-CoV-2 antibodies of employees shows low transmission working i...

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E3-specific degrader discovery by dynamic tracing of substrate receptor abundance

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A Multi-Crystal Method for Extracting Obscured Signal from Crystallographic Electron Density

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