Pin1 inhibition improves the efficacy of ralaniten compounds that bind to the N-terminal domain of a...
Pin1 inhibition improves the efficacy of ralaniten compounds that bind to the N-terminal domain of androgen receptor
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Therapies for lethal castration-resistant prostate cancer (CRPC) are an unmet medical need. One mechanism underlying CRPC and resistance to hormonal therapies is the expression of constitutively active splice variant(s) of androgen receptor (AR-Vs) that lack its C-terminus ligand-binding domain. Transcriptional activities of AR-Vs and full-length A...
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Full title
Pin1 inhibition improves the efficacy of ralaniten compounds that bind to the N-terminal domain of androgen receptor
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TN_cdi_doaj_primary_oai_doaj_org_article_5e621729cae84ceba3bb46f9ecec1999
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5e621729cae84ceba3bb46f9ecec1999
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ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-021-01927-3
