A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export
A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Cholesterol import in mammalian cells is mediated by the LDL receptor pathway. Here, we perform a genome-wide CRISPR screen using an endogenous cholesterol reporter and identify >100 genes involved in LDL-cholesterol import. We characterise C18orf8 as a core subunit of the mammalian Mon1-Ccz1 guanidine exchange factor (GEF) for Rab7, required for c...
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Full title
A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export
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TN_cdi_doaj_primary_oai_doaj_org_article_5ea86788f5ff452193f198cb9ba6bdd4
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5ea86788f5ff452193f198cb9ba6bdd4
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-19032-0
