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Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactor...

Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactor...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5f004020de71409998164819cc158a1c

Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons

About this item

Full title

Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2020-05, Vol.11 (1), p.2188-2188, Article 2188

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Olfactory receptor neurons (ORNs) use odour-induced intracellular cAMP surge to gate cyclic nucleotide-gated nonselective cation (CNG) channels in cilia. Prolonged exposure to cAMP causes calmodulin-dependent feedback-adaptation of CNG channels and attenuates neural responses. On the other hand, the odour-source searching behaviour requires ORNs to...

Alternative Titles

Full title

Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_5f004020de71409998164819cc158a1c

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5f004020de71409998164819cc158a1c

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-020-15917-2

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