Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactor...
Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Olfactory receptor neurons (ORNs) use odour-induced intracellular cAMP surge to gate cyclic nucleotide-gated nonselective cation (CNG) channels in cilia. Prolonged exposure to cAMP causes calmodulin-dependent feedback-adaptation of CNG channels and attenuates neural responses. On the other hand, the odour-source searching behaviour requires ORNs to...
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Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons
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TN_cdi_doaj_primary_oai_doaj_org_article_5f004020de71409998164819cc158a1c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5f004020de71409998164819cc158a1c
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-15917-2
