In vitro and in vivo activity of R- and S- praziquantel enantiomers and the main human metabolite tr...
In vitro and in vivo activity of R- and S- praziquantel enantiomers and the main human metabolite trans-4-hydroxy-praziquantel against Schistosoma haematobium
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England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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Contents
Praziquantel (PZQ) is the mainstay of schistosomiasis control and has been successfully used for decades. However, its mechanism of action is not fully understood. While the majority of studies have been conducted on Schistosoma mansoni, it is not known which enantiomer, R- or S-praziquantel (R-/S-PZQ), is responsible for the activity on Schistosom...
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Full title
In vitro and in vivo activity of R- and S- praziquantel enantiomers and the main human metabolite trans-4-hydroxy-praziquantel against Schistosoma haematobium
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TN_cdi_doaj_primary_oai_doaj_org_article_5f11034e7df24df0817f7104c86dc6da
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5f11034e7df24df0817f7104c86dc6da
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ISSN
1756-3305
E-ISSN
1756-3305
DOI
10.1186/s13071-017-2293-3
