Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase
Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The suppressor of cytokine signaling 2 (SOCS2) acts as substrate recognition subunit of a Cullin5 E3 ubiquitin ligase complex. SOCS2 binds to phosphotyrosine-modified epitopes as degrons for ubiquitination and proteasomal degradation, yet the molecular basis of substrate recognition has remained elusive. Here, we report co-crystal structures of SOC...
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Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase
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TN_cdi_doaj_primary_oai_doaj_org_article_5f64f9c2c7dd475d9276013f7571de57
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5f64f9c2c7dd475d9276013f7571de57
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-10190-4
