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Widespread chromatin context-dependencies of DNA double-strand break repair proteins

Widespread chromatin context-dependencies of DNA double-strand break repair proteins

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6009cbab086a43759a3f31b9c33c7f5d

Widespread chromatin context-dependencies of DNA double-strand break repair proteins

About this item

Full title

Widespread chromatin context-dependencies of DNA double-strand break repair proteins

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2024-06, Vol.15 (1), p.5334-14, Article 5334

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

DNA double-strand breaks are repaired by multiple pathways, including non-homologous end-joining (NHEJ) and microhomology-mediated end-joining (MMEJ). The balance of these pathways is dependent on the local chromatin context, but the underlying mechanisms are poorly understood. By combining knockout screening with a dual MMEJ:NHEJ reporter inserted...

Alternative Titles

Full title

Widespread chromatin context-dependencies of DNA double-strand break repair proteins

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_6009cbab086a43759a3f31b9c33c7f5d

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6009cbab086a43759a3f31b9c33c7f5d

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-024-49232-x

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