Uncoupling conformational states from activity in an allosteric enzyme
Uncoupling conformational states from activity in an allosteric enzyme
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
ATP-phosphoribosyltransferase (ATP-PRT) is a hexameric enzyme in conformational equilibrium between an open and seemingly active state and a closed and presumably inhibited form. The structure-function relationship of allosteric regulation in this system is still not fully understood. Here, we develop a screening strategy for modulators of ATP-PRT...
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Full title
Uncoupling conformational states from activity in an allosteric enzyme
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TN_cdi_doaj_primary_oai_doaj_org_article_603702800eb7417086645e28e6a8150e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_603702800eb7417086645e28e6a8150e
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-00224-0
