Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor
Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell proliferation. However, the regulation of amino acid uptake is not well-understood. Here we describe a role for asparagine as an amino acid exchange factor: intracellular asparagine exchanges with extracellular amino acids. Through asparagine synthetase knockdown...
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Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor
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TN_cdi_doaj_primary_oai_doaj_org_article_60bac93b7d0d4ccbba58a39386a3ee0d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_60bac93b7d0d4ccbba58a39386a3ee0d
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms11457
