A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry
A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry
About this item
Full title
Author / Creator
Zhu, Yunkai , Feng, Fei , Hu, Gaowei , Wang, Yuyan , Yu, Yin , Zhu, Yuanfei , Xu, Wei , Cai, Xia , Sun, Zhiping , Han, Wendong , Ye, Rong , Qu, Di , Ding, Qiang , Huang, Xinxin , Chen, Hongjun , Xu, Wei , Xie, Youhua , Cai, Qiliang , Yuan, Zhenghong and Zhang, Rong
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The global spread of SARS-CoV-2 is posing major public health challenges. One feature of SARS-CoV-2 spike protein is the insertion of multi-basic residues at the S1/S2 subunit cleavage site. Here, we find that the virus with intact spike (Sfull) preferentially enters cells via fusion at the plasma membrane, whereas a clone (Sdel) with deletion disr...
Alternative Titles
Full title
A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_614198775ef44e57a0a5f7bb249a104c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_614198775ef44e57a0a5f7bb249a104c
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-21213-4
