Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistanc...
Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer
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England: eLife Science Publications, Ltd
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Language
English
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England: eLife Science Publications, Ltd
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Contents
In prostate cancer, resistance to the antiandrogen enzalutamide (Enz) can occur through bypass of androgen receptor (AR) blockade by the glucocorticoid receptor (GR). In contrast to fixed genomic alterations, here we show that GR-mediated antiandrogen resistance is adaptive and reversible due to regulation of GR expression by a tissue-specific enha...
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Full title
Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_61db683fcfe74955afcc80092315405e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_61db683fcfe74955afcc80092315405e
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.27861
