YAP regulates cell mechanics by controlling focal adhesion assembly
YAP regulates cell mechanics by controlling focal adhesion assembly
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Author / Creator
Nardone, Giorgia , Oliver-De La Cruz, Jorge , Vrbsky, Jan , Martini, Cecilia , Pribyl, Jan , Skládal, Petr , Pešl, Martin , Caluori, Guido , Pagliari, Stefania , Martino, Fabiana , Maceckova, Zuzana , Hajduch, Marian , Sanz-Garcia, Andres , Pugno, Nicola Maria , Stokin, Gorazd Bernard and Forte, Giancarlo
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Hippo effectors YAP/TAZ act as on–off mechanosensing switches by sensing modifications in extracellular matrix (ECM) composition and mechanics. The regulation of their activity has been described by a hierarchical model in which elements of Hippo pathway are under the control of focal adhesions (FAs). Here we unveil the molecular mechanism by which...
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Full title
YAP regulates cell mechanics by controlling focal adhesion assembly
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_6257312755974ce381c3c1ab209da290
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6257312755974ce381c3c1ab209da290
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms15321
