SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant can...
SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Targeted inhibition of the ERK-MAPK pathway, upregulated in a majority of human cancers, has been hindered in the clinic by drug resistance and toxicity. The MRAS-SHOC2-PP1 (SHOC2 phosphatase) complex plays a key role in RAF-ERK pathway activation by dephosphorylating a critical inhibitory site on RAF kinases. Here we show that genetic inhibition o...
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Full title
SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers
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TN_cdi_doaj_primary_oai_doaj_org_article_63c728d50eef448aa2fdb9117a059704
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_63c728d50eef448aa2fdb9117a059704
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-10367-x
