Differential regulation of progranulin derived granulin peptides
Differential regulation of progranulin derived granulin peptides
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal lobar degeneration (FTLD). PGRN is comprised of 7.5 granulin repeats and is processed into individual granulin peptides in the lysosome. However, very little is known about the levels and regulations of individual granulin peptides due to the lack of specific antibodies.<...
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Full title
Differential regulation of progranulin derived granulin peptides
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TN_cdi_doaj_primary_oai_doaj_org_article_63dfd99a4a9848ad96214c257ffd37aa
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_63dfd99a4a9848ad96214c257ffd37aa
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ISSN
1750-1326
E-ISSN
1750-1326
DOI
10.1186/s13024-021-00513-9
