DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents a...
DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response
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Author / Creator
Yulyaningsih, Ernie , Suh, Jung H , Fanok, Melania , Chau, Roni , Solanoy, Hilda , Takahashi, Ryan , Bakardjiev, Anna I , Becerra, Isabel , Benitez, N Butch , Chiu, Chi-Lu , Davis, Sonnet S , Dowdle, William E , Earr, Timothy , Estrada, Anthony A , Gill, Audrey , Ha, Connie , Haddick, Patrick C G , Henne, Kirk R , Larhammar, Martin , Leung, Amy W-S , Maciuca, Romeo , Memarzadeh, Bahram , Nguyen, Hoang N , Nugent, Alicia A , Osipov, Maksim , Ran, Yingqing , Rebadulla, Kevin , Roche, Elysia , Sandmann, Thomas , Wang, Jing , Lewcock, Joseph W , Scearce-Levie, Kimberly , Kane, Lesley A and Sanchez, Pascal E
Publisher
England: eLife Science Publications, Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: eLife Science Publications, Ltd
Subjects
More information
Scope and Contents
Contents
The integrated stress response (ISR) is a conserved pathway in eukaryotic cells that is activated in response to multiple sources of cellular stress. Although acute activation of this pathway restores cellular homeostasis, intense or prolonged ISR activation perturbs cell function and may contribute to neurodegeneration. DNL343 is an investigationa...
Alternative Titles
Full title
DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response
Authors, Artists and Contributors
Author / Creator
Suh, Jung H
Fanok, Melania
Chau, Roni
Solanoy, Hilda
Takahashi, Ryan
Bakardjiev, Anna I
Becerra, Isabel
Benitez, N Butch
Chiu, Chi-Lu
Davis, Sonnet S
Dowdle, William E
Earr, Timothy
Estrada, Anthony A
Gill, Audrey
Ha, Connie
Haddick, Patrick C G
Henne, Kirk R
Larhammar, Martin
Leung, Amy W-S
Maciuca, Romeo
Memarzadeh, Bahram
Nguyen, Hoang N
Nugent, Alicia A
Osipov, Maksim
Ran, Yingqing
Rebadulla, Kevin
Roche, Elysia
Sandmann, Thomas
Wang, Jing
Lewcock, Joseph W
Scearce-Levie, Kimberly
Kane, Lesley A
Sanchez, Pascal E
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_6521500dd1424027bebffc6920eba56b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6521500dd1424027bebffc6920eba56b
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.92173
