Hyperaminoacidemia induces pancreatic α cell proliferation via synergism between the mTORC1 and CaSR...
Hyperaminoacidemia induces pancreatic α cell proliferation via synergism between the mTORC1 and CaSR-Gq signaling pathways
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Glucagon has emerged as a key regulator of extracellular amino acid (AA) homeostasis. Insufficient glucagon signaling results in hyperaminoacidemia, which drives adaptive proliferation of glucagon-producing α cells. Aside from mammalian target of rapamycin complex 1 (mTORC1), the role of other AA sensors in α cell proliferation has not been describ...
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Full title
Hyperaminoacidemia induces pancreatic α cell proliferation via synergism between the mTORC1 and CaSR-Gq signaling pathways
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TN_cdi_doaj_primary_oai_doaj_org_article_654699dbaee24375b1033c131a876439
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_654699dbaee24375b1033c131a876439
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-35705-4
