Assessing proteinase K resistance of fish prion proteins in a scrapie-infected mouse neuroblastoma c...
Assessing proteinase K resistance of fish prion proteins in a scrapie-infected mouse neuroblastoma cell line
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Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Contents
The key event in prion pathogenesis is the structural conversion of the normal cellular protein, PrP(C), into an aberrant and partially proteinase K resistant isoform, PrP(Sc). Since the minimum requirement for a prion disease phenotype is the expression of endogenous PrP in the host, species carrying orthologue prion genes, such as fish, could in...
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Full title
Assessing proteinase K resistance of fish prion proteins in a scrapie-infected mouse neuroblastoma cell line
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TN_cdi_doaj_primary_oai_doaj_org_article_6573caba9c344f43aafc97283d84ff4c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6573caba9c344f43aafc97283d84ff4c
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ISSN
1999-4915
E-ISSN
1999-4915
DOI
10.3390/v6114398
