Mutational signatures of ionizing radiation in second malignancies
Mutational signatures of ionizing radiation in second malignancies
About this item
Full title
Author / Creator
Behjati, Sam , Gundem, Gunes , Wedge, David C. , Roberts, Nicola D. , Tarpey, Patrick S. , Cooke, Susanna L. , Van Loo, Peter , Alexandrov, Ludmil B. , Ramakrishna, Manasa , Davies, Helen , Nik-Zainal, Serena , Hardy, Claire , Latimer, Calli , Raine, Keiran M. , Stebbings, Lucy , Menzies, Andy , Jones, David , Shepherd, Rebecca , Butler, Adam P. , Teague, Jon W. , Jorgensen, Mette , Khatri, Bhavisha , Pillay, Nischalan , Shlien, Adam , Futreal, P. Andrew , Badie, Christophe , McDermott, Ultan , Bova, G. Steven , Richardson, Andrea L. , Flanagan, Adrienne M. , Stratton, Michael R. , Campbell, Peter J. and ICGC Prostate Group
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Ionizing radiation is a potent carcinogen, inducing cancer through DNA damage. The signatures of mutations arising in human tissues following
in vivo
exposure to ionizing radiation have not been documented. Here, we searched for signatures of ionizing radiation in 12 radiation-associated second malignancies of different tumour types. Two sign...
Alternative Titles
Full title
Mutational signatures of ionizing radiation in second malignancies
Authors, Artists and Contributors
Author / Creator
Gundem, Gunes
Wedge, David C.
Roberts, Nicola D.
Tarpey, Patrick S.
Cooke, Susanna L.
Van Loo, Peter
Alexandrov, Ludmil B.
Ramakrishna, Manasa
Davies, Helen
Nik-Zainal, Serena
Hardy, Claire
Latimer, Calli
Raine, Keiran M.
Stebbings, Lucy
Menzies, Andy
Jones, David
Shepherd, Rebecca
Butler, Adam P.
Teague, Jon W.
Jorgensen, Mette
Khatri, Bhavisha
Pillay, Nischalan
Shlien, Adam
Futreal, P. Andrew
Badie, Christophe
McDermott, Ultan
Bova, G. Steven
Richardson, Andrea L.
Flanagan, Adrienne M.
Stratton, Michael R.
Campbell, Peter J.
ICGC Prostate Group
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_6591661632a94c5d9e36a5a48f8dcf2c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6591661632a94c5d9e36a5a48f8dcf2c
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms12605
