A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver...
A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer
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Publisher
England: eLife Sciences Publications, Ltd
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Language
English
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Publisher
England: eLife Sciences Publications, Ltd
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Contents
The dependency of cancer cells on glutamine may be exploited therapeutically as a new strategy for treating cancers that lack druggable driver genes. Here we found that human liver cancer was dependent on extracellular glutamine. However, targeting glutamine addiction using the glutaminase inhibitor CB-839 as monotherapy had a very limited anticanc...
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Full title
A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_67844f9e629f4631a5c877af93e2e1e6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_67844f9e629f4631a5c877af93e2e1e6
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.56749
