Spatio-temporal transcriptomics of chromothriptic SHH-medulloblastoma identifies multiple genetic cl...
Spatio-temporal transcriptomics of chromothriptic SHH-medulloblastoma identifies multiple genetic clones that resist treatment and drive relapse
About this item
Full title
Author / Creator
Kats, Ilia , Simovic-Lorenz, Milena , Schreiber, Hannah Sophia , Sant, Pooja , Mallm, Jan-Philipp , Körber, Verena , Li, Albert , Velmurugan, Pravin , Heuer, Sophie , Kües, Luisa , Devens, Frauke , Sill, Martin , Jugold, Manfred , Moustafa, Mahmoud , Abdollahi, Amir , Winkler, Frank , Korshunov, Andrey , Pfister, Stefan M. , Stegle, Oliver and Ernst, Aurélie
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Paediatric medulloblastomas with chromothripsis are characterised by high genomic instability and are among the tumours with the worst prognosis. However, the molecular makeup and the determinants of the aggressiveness of chromothriptic medulloblastoma are not well understood. Here, we apply spatial transcriptomics to profile a cohort of 13 chromot...
Alternative Titles
Full title
Spatio-temporal transcriptomics of chromothriptic SHH-medulloblastoma identifies multiple genetic clones that resist treatment and drive relapse
Authors, Artists and Contributors
Author / Creator
Simovic-Lorenz, Milena
Schreiber, Hannah Sophia
Sant, Pooja
Mallm, Jan-Philipp
Körber, Verena
Li, Albert
Velmurugan, Pravin
Heuer, Sophie
Kües, Luisa
Devens, Frauke
Sill, Martin
Jugold, Manfred
Moustafa, Mahmoud
Abdollahi, Amir
Winkler, Frank
Korshunov, Andrey
Pfister, Stefan M.
Stegle, Oliver
Ernst, Aurélie
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_684cf9f4eeb14996906d77c97e287ebf
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_684cf9f4eeb14996906d77c97e287ebf
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-54709-w
