Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic repro...
Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Dysregulation of Th17 and Treg cells contributes to the pathophysiology of many autoimmune diseases. Herein, we show that itaconate, an immunomodulatory metabolite, inhibits Th17 cell differentiation and promotes Treg cell differentiation by orchestrating metabolic and epigenetic reprogramming. Mechanistically, itaconate suppresses glycolysis and o...
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Full title
Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming
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TN_cdi_doaj_primary_oai_doaj_org_article_68f268483d2847d9a8c8f89d4540a446
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_68f268483d2847d9a8c8f89d4540a446
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-36594-x
