Evaluating the effectiveness of simvastatin in slowing the progression of disability in secondary pr...
Evaluating the effectiveness of simvastatin in slowing the progression of disability in secondary progressive multiple sclerosis (MS-STAT2): protocol for a multicentre, randomised controlled, double-blind, phase 3 clinical trial in the UK
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Author / Creator
Blackstone, James , Williams, Thomas , Nicholas, Jennifer M , Bordea, Ekaterina , De Angelis, Floriana , Bianchi, Alessia , Calvi, Alberto , Doshi, Anisha , John, Nevin , Apap Mangion, Sean , Wade, Charles , Merry, Rachel , Barton, Gil , Lyle, Dawn , Jarman, Elisabeth , Mahad, Don , Shehu, Abdullah , Arun, Tarunya , McDonnell, Gavin , Geraldes, Ruth , Craner, Matthew , Hillier, Charles , Ganesalingam, Jeban , Fisniku, Leonora , Hobart, Jeremy , Spilker, Cord , Robertson, Neil , Kalra, Seema , Pluchino, Stefano , Harikrishnan, Sreedharan , Mattoscio, Miriam , Harrower, Timothy , Young, Carolyn , Lee, Martin , Chhetri, Suresh , Ahmed, Fayyaz , Rog, David , Silber, Eli , Gallagher, Paul , Duddy, Martin , Straukiene, Agne , Nicholas, Richard , Rice, Claire , Nixon, Stuart J , Beveridge, Judy , Hawton, Annie , Tebbs, Susan , Braisher, Marie , Giovannoni, Gavin , Ciccarelli, Olga , Greenwood, John , Thompson, Alan J , Hunter, Rachael , Pavitt, Sue , Pearson, Owen , Evangelou, Nikos , Sharrack, Basil , Galea, Ian , Chandran, Siddharthan , Ford, Helen L , Frost, Chris and Chataway, Jeremy
Publisher
England: British Medical Journal Publishing Group
Journal title
Language
English
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Publisher
England: British Medical Journal Publishing Group
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Scope and Contents
Contents
IntroductionThere remains a high unmet need for disease-modifying therapies that can impact disability progression in secondary progressive multiple sclerosis (SPMS). Following positive results of the phase 2 MS-STAT study, the MS-STAT2 phase 3 trial will evaluate the efficacy and cost-effectiveness of repurposed high-dose simvastatin in slowing th...
Alternative Titles
Full title
Evaluating the effectiveness of simvastatin in slowing the progression of disability in secondary progressive multiple sclerosis (MS-STAT2): protocol for a multicentre, randomised controlled, double-blind, phase 3 clinical trial in the UK
Authors, Artists and Contributors
Author / Creator
Williams, Thomas
Nicholas, Jennifer M
Bordea, Ekaterina
De Angelis, Floriana
Bianchi, Alessia
Calvi, Alberto
Doshi, Anisha
John, Nevin
Apap Mangion, Sean
Wade, Charles
Merry, Rachel
Barton, Gil
Lyle, Dawn
Jarman, Elisabeth
Mahad, Don
Shehu, Abdullah
Arun, Tarunya
McDonnell, Gavin
Geraldes, Ruth
Craner, Matthew
Hillier, Charles
Ganesalingam, Jeban
Fisniku, Leonora
Hobart, Jeremy
Spilker, Cord
Robertson, Neil
Kalra, Seema
Pluchino, Stefano
Harikrishnan, Sreedharan
Mattoscio, Miriam
Harrower, Timothy
Young, Carolyn
Lee, Martin
Chhetri, Suresh
Ahmed, Fayyaz
Rog, David
Silber, Eli
Gallagher, Paul
Duddy, Martin
Straukiene, Agne
Nicholas, Richard
Rice, Claire
Nixon, Stuart J
Beveridge, Judy
Hawton, Annie
Tebbs, Susan
Braisher, Marie
Giovannoni, Gavin
Ciccarelli, Olga
Greenwood, John
Thompson, Alan J
Hunter, Rachael
Pavitt, Sue
Pearson, Owen
Evangelou, Nikos
Sharrack, Basil
Galea, Ian
Chandran, Siddharthan
Ford, Helen L
Frost, Chris
Chataway, Jeremy
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_69619bde66e34a6986cbeaf0b8bdc802
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_69619bde66e34a6986cbeaf0b8bdc802
Other Identifiers
ISSN
2044-6055
E-ISSN
2044-6055
DOI
10.1136/bmjopen-2024-086414
